زگیل تناسلی – پرسش ۱۶۴۱۳۵

• راحله سه شنبه ۲۱ آبان ۹۸( ۵ سال پیش) تعداد بازدید: ۱۴۹ زگیل تناسلی
  انواع پرخطر ویروس پاپیلومای انسانی( نوع ۱۶،۱۸ و ۳۳) علت ۳۰% از موارد سرطان پستان در نواحی مختلف دنیا هستند. سرطان پستان ناشی از این ویروس اغلب تهاجمی بوده و در زنان جوان تر رخ می دهد. انکو پروتئین های E6 و E7ویروس، با تداخل در سیکل سلولی و تحریک چند فرآیند مولکولی منجر به تغییر شکل بدخیمی در سلول های آلوده به ویروس می شوند.
  تعدادی از مطالعات ارتباط میان پاپیلوما ویروس انسانی (HPV) و سرطان ریه را مطرح کرده اند .
  جناب دکتر سلام خسته نباشید خواستم بپرسم از خدمتتون که چطور این ویروس باعث سرطان سینه میشه مگه فقط تو بافت پوست نیست خواهش میکنم توضیح علمی بفرمایید خیلی خیلی نگرانم با وجود نوع پرخطر در بدن و ماندگاریش کی و در چه شرایطی بدن آمادگی گرفتن سرطان سینه رو داره؟
  1. دکتر محمد جباری سه شنبه ۲۱ آبان ۹۸( ۵ سال پیش)

     سلام

     https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036645/

     Of 22 previous studies on HPV in breast cancer till date, 15 reported presence of HPV infection in breast cancer and the authors have tried to put forward their possible explanation for detection of HPV DNA in breast cancer. Although the spreading of genital HPV infection from one site to the other is not established, a few studies have reported detection of genital HPVs in peripheral blood lymphocytes of patients with urino-genital cancers [۶۴–۶۷] and head & neck cancers [۶۸]. So, it has been suggested that, there is a possibility of systemic spread of oncogenic virus through organ perfusion [۶۹] facilitating its entry into the breast through circulation. For this reason we tried to look for HPV DNA in blood samples of 142 breast cancer patients from Bangalore, North-east region, J & K and Goa but none of them was found positive for HPV DNA. However, the detection of genital HPVs in the nipple and areolar region reported by de Villers et al. [۴۴] suggests an alternative and perhaps more likely route of infection. Because of varied sexual behavior it is possible that genital HPVs may transmit to breast through oro-genital route or directly through genital-breast contacts. So there could be transmission of HPV infection by mechanical path where the virus is scrubbed through the skin [۴۴]. However, the lack of detection of HPV in breast cancer indicates that the virus has no role to play in breast carcinogenesis in Indian women.

  2. دکتر محمد جباری سه شنبه ۲۱ آبان ۹۸( ۵ سال پیش)

     سلام

     https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036645/

     Of 22 previous studies on HPV in breast cancer till date, 15 reported presence of HPV infection in breast cancer and the authors have tried to put forward their possible explanation for detection of HPV DNA in breast cancer. Although the spreading of genital HPV infection from one site to the other is not established, a few studies have reported detection of genital HPVs in peripheral blood lymphocytes of patients with urino-genital cancers and head & neck cancers. So, it has been suggested that, there is a possibility of systemic spread of oncogenic virus through organ perfusion facilitating its entry into the breast through circulation. For this reason we tried to look for HPV DNA in blood samples of 142 breast cancer patients from Bangalore, North-east region, J & K and Goa but none of them was found positive for HPV DNA. However, the detection of genital HPVs in the nipple and areolar region reported by de Villers et al. suggests an alternative and perhaps more likely route of infection. Because of varied sexual behavior it is possible that genital HPVs may transmit to breast through oro-genital route or directly through genital-breast contacts. So there could be transmission of HPV infection by mechanical path where the virus is scrubbed through the skin . However, the lack of detection of HPV in breast cancer indicates that the virus has no role to play in breast carcinogenesis in Indian women.